![]() Graduated compression stockings for prevention of deep vein thrombosis during a hospital stayĭeep vein thrombosis (DVT) is a blood clot that forms in a vein deep in the body, usually in the leg or pelvic veins. Limited data were available to accurately assess the incidence of adverse effects and complications with the use of GCS as these were not routinely quantitatively reported in the included studies. ![]() None of the medical patients in either group developed a proximal DVT, and the incidence of PE was not reported. ![]() The Peto OR was 0.12 (95% CI 0.03 to 0.51 low‐quality evidence) with an overall effect favouring treatment with GCS (P = 0.004). We downgraded the evidence for proximal DVT due to low event rate (imprecision).īased on the results from one trial focusing on medical patients admitted following acute myocardial infarction, 0 of 80 (0%) legs developed DVT in the GCS group and 8 of 80 (10%) legs developed DVT in the control group. The Peto OR was 0.26 (95% CI 0.13 to 0.53 875 units moderate‐quality evidence) with an overall effect favouring treatment with GCS (P < 0.001). Based on results from seven included studies, the incidence of proximal DVT was 7 of 437 units (1.6%) in the GCS group and 28 of 438 (6.4%) in the control group. The Peto OR was 0.35 (95% CI 0.28 to 0.44 high‐quality evidence), with an overall effect favouring treatment with GCS (P < 0.001). Combining results from 19 trials focusing on surgical patients, 134 of 1365 (9.8%) units developed DVT in the GCS group compared to 282 of 1328 (21.2%) units in the control group. We carried out subgroup analysis by speciality (surgical or medical patients). We downgraded the quality of the evidence for proximal DVT and PE due to low event rate (imprecision) and lack of routine screening for PE (inconsistency). The Peto OR was 0.38 (95% CI 0.15 to 0.96 5 studies 569 participants low‐quality evidence) with an overall effect favouring treatment with GCS (P = 0.04). Combining results from five studies, all based on surgical patients, the incidence of PE was 5 of 283 (2%) participants in the GCS group and 14 of 286 (5%) in the control group. The Peto OR was 0.26 (95% CI 0.13 to 0.53 8 studies 1035 units moderate‐quality evidence) with an overall effect favouring treatment with GCS (P < 0.001). The Peto odds ratio (OR) was 0.35 (95% confidence interval (CI) 0.28 to 0.43 20 studies 2853 units high‐quality evidence), showing an overall effect favouring treatment with GCS (P < 0.001).īased on results from eight included studies, the incidence of proximal DVT was 7 of 517 (1%) units in the GCS group and 28 of 518 (5%) units in the control group. In the GCS group, 134 of 1445 units developed DVT (9%) in comparison to the control group (without GCS), in which 290 of 1408 units developed DVT (21%). We were able to pool the data from 20 studies reporting the incidence of DVT. The included studies were at an overall low risk of bias. Duration of follow‐up ranged from seven to 14 days. In the majority of the included studies DVT was identified by the radioactive I 125 uptake test. ![]() Graduated compression stockings were applied on the day before surgery or on the day of surgery and were worn up until discharge or until the participants were fully mobile. Of these 20 trials, 10 included patients undergoing general surgery six included patients undergoing orthopaedic surgery three individual trials included patients undergoing neurosurgery, cardiac surgery, and gynaecological surgery, respectively and only one trial included medical patients. We included 20 RCTs involving a total of 1681 individual participants and 1172 individual legs (2853 analytic units). ![]()
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